RS 100329 ( RS-100329 )

产品货号. M27696 CAS No. 1215654-26-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

RS 100329
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.
产品描述

RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.(In Vitro):In intact CHO-K1 cells expressing human cloned alpha1A-, alpha1B- and alpha1D-AR showed nanomolar affinity and significant alpha1A-AR subtype selectivity for RS 100329 hydrochloride (pKi 9.6: 126 and 50 fold selectivity) over the alpha1B- and alpha1D-AR subtypes respectively. Noradrenaline-induced contractions of human lower urinary tract (LUT) tissues or rabbit bladder neck were competitively antagonized by RS 100329 hydrochloride (pA2 9.2 and 9.2).
同义词

RS-100329
通路

Angiogenesis
靶点

Adrenergic Receptor
受体

EGFR;c-Met
研究领域

——
适应症

——

1.Dokla EME, et al. 1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC. Eur J Med Chem. 2019 Aug 9;182:111607.

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